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Formulation Forum

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See Dow Development Laboratories’ FormulationForum for articles and resources on various topical drug product development topics of interest.

How many pea-sized amounts are you going to use?

How many pea-sized amounts are you going to use?

The FDA Inactive Ingredient Database (IID) is heavily used by formulators when developing drug products.  This resource has been available since 19871 and has since informed the inactive ingredient (excipient) selections and concentrations made by formulation...

CMC Roadmap for Topical Drug Products

CMC Roadmap for Topical Drug Products

CMC is critical to a successful topical drug product program.  Important aspects of CMC that are unique to topical products are discussed in this presentation.

Scale-Up of Topical Products: Math Matters

Scale-Up of Topical Products: Math Matters

Proper scale up of a 1 kg batch to a 1,000+ kg batch takes engineering effort to execute properly.  Why is this so difficult?  The short answer is because of the math.  The physical forces on a semi-solid product while manufacturing a 1 kg laboratory batch vs. that of...

To Suspend or Not to Suspend

To Suspend or Not to Suspend

Pros and Cons of topical products containing a suspended API Prescription drug products contain an active pharmaceutical ingredient (API)1. While traditional topical drug product development focuses on dissolving the API, challenges can arise from dissolved systems....